How to Use Sodium Hyaluronate vs Hyaluronic Acid

Sodium hyaluronate penetrates deeper and works better in serums, while hyaluronic acid sits on surface and works better in heavier creams.

  1. Know your molecule size. Sodium hyaluronate is the salt form of hyaluronic acid with smaller molecules that actually sink into skin. Hyaluronic acid has larger molecules that create a moisture barrier on top.
  2. Layer sodium hyaluronate first. Apply sodium hyaluronate serums on damp skin before any oils or heavy creams. The smaller molecules need a clear path to penetrate deeper layers.
  3. Use hyaluronic acid to seal. Apply hyaluronic acid in heavier formulas last to lock everything in. It creates a plumping film that holds moisture at the surface.
  4. Match to your skin type. Oily skin responds better to sodium hyaluronate serums. Dry skin benefits more from hyaluronic acid in rich creams that provide surface protection.